Possible antithrombotic properties of propolis

Abstract

Naoki Ohkura, Keiji Maruyama, Fumiko Kihara-Negishi

The formation of thrombi in blood vessels results in thrombosis that is responsible for a considerable morbidity and mortality because it is associated with arterial diseases such as myocardial infarction, stroke, and peripheral occlusive disease in addition to venous thromboembolic disorders. Pharmaceutical agents such as anticoagulant agents and antiplatelet agents are applied for the prevention of the recurrence of thrombotic disorders. However, the use of these pharmaceuticals can result in side effects such as bleeding, as well as renal and hepatic disorders. The prevention and treatment of dis-eases using functional foods and alternative medicines have recently attracted an atten-tion. Functional foods and alternative medicines with possible antithrombotic properties that have been used for many years are now receiving a significant focus in terms of the treatment and prevention of thrombosis. As they have already been used for so long, they are likely to be safe. Propolis is a hive product comprising resinous materials collected by bees from plants, and it includes various chemical compounds. Various bio-logical activities of propolis have been indicated, and propolis is used as folk medicine and health supplement worldwide. This report reviews the possibility of using propolis as an antithrombotic agent.