Microcirculation in rats with thermal trauma under the influence of Royal jelly

Abstract

Anna G. Soloveva, P. V. Peretyagin

Aim: The work was devoted to study the effect of Royal jelly (RJ) on the microcirculation during thermal injury in the experiment. Materials and Methods: The study was conducted on white Wistar rats weighing 180-220 g. Three groups of animals were formed: Intact group – Healthy animals (n = 10), control group – Animals with thermal injury (n = 10), and experimental group – Animals with thermal injury treated with RJ (n = 8). The method of laser Doppler flowmetry was used for the study of microcirculation. Results: The decrease of the intensity of microcirculation and the growth of bypass indicator was marked in animals with the burn. The results showed that the use of RJ in the treatment of thermal injury contributes to the stimulation of active factors (endothelial, neurogenic, and myogenic) of regulation of microcirculation, showing a potentiating effect in the healing of wounds. The analysis of passive factors of the microcirculation reflecting the blood flow out of the system of microcirculation revealed a statistically significant decrease in respiratory waves associated with a venular link on 24% in thermal injury in comparison to the intact group of animals. The tendency to increase of the amplitude of respiratory waves was marked by 13% in comparison to the control group of rats under the influence of RJ. Conclusion: The results showed that the use of RJ in the complex treatment of thermal injury contributes to the normalization of microcirculation. RJ stimulates active factors of the regulation of microcirculation, improves a blood circulation, accelerating the reparative processes in the area of the burn.