Eastern hornet (Vespa orientalis) venom influence on Ehrlich ascites carcinoma

Abstract

Marwa Gomaa, Ashraf Sherif Fatehy

Introduction: Wasp’s venom has been playing a great role in the recent and coming years. Although it has attracted much less attention than bee venom, extensive research over recent decades has shown its pharmacological properties.Aim: The objective of this study is to examine the effect of four wasp’s venom concen-trates (50, 75, 150, and 300 μg/mouse) on cancer cells compared with silymarin.Methods: Histopathological studies were done in the treated and untreated infected liver samples and the viability percentage was calculated.Results: The differences between treatments and control in viable cells were 76, 3, and 18 in wasp’s venom concentrates of 50 and 75 μg/mouse and silymarin, respectively. The 150 and 300 μg/mouse of wasp’s venom concentrate caused complete death rate.Conclusion: Wasp’s venom was measured as one of the top treatments and shows posi-tive results, affecting the cancer cells, especially at wasp’s venom concentrate of 50 μg/mouse.