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Wild Honey Facilitates Antibacterial Efficacy of Penicillin and Amoxicillin-Clavulanic Acid.

Mahi Khan, Zahirul Islam, Ayreen S. Chowdhury, Syed Ali Yousuf, Md. R. Amin, Md. Abu Rayhan.

Abstract
Background: Antibacterial efficacy of honey has been well acknowledged from ancient to modern society. Utilizing a wild honey, the present strategy of the study was chosen to address an unfilled demand for finding a complement of penicillin analogues which have already been reported resistant in many cases.

Methods: In this study, penicillin and amoxiclav were trialed against four clinically resistant bacteria – two gram-positives (Staphylococcus aureus and Streptococcus pyogenes) and two gram-negatives (Klebsiella pneumoniae and Acinetobacter baumannii). Afterwards, these bacteria were exposed to different concentrations of a natural wild honey. Finally, the honey was used in conjugation with penicillin and amoxiclav individually. Zone of inhibition, minimum inhibitory and bactericidal concentrations were observed in this regard.

Results: The wild honey showed great potential to inhibit bacterial growth at its lowest dose given (6.25%) both against Staphylococcus (48%) and Streptococcus species (45%) but could not exhibit any bactericidal effect alone. However, it greatly influenced both penicillin (100%) against Acinetobacter and amoxiclav (93%) against Klebsiella species whereas these two antibiotics could not demonstrate good antibacterial effect when applied individually against these bacteria.

Conclusion: All findings suggested that wild honey not only possess inhibitory effect but also Facilitates other agents’ action, thereby, generating a scope for research for identifying new potential antibacterial agents.

Key words: Wild Honey, Physicochemical properties, Zone of Inhibition, MIC, MBC


 
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How to Cite this Article
Pubmed Style

Khan M, Islam Z, Chowdhury AS, Yousuf SA, Amin MR, Rayhan MA. Wild Honey Facilitates Antibacterial Efficacy of Penicillin and Amoxicillin-Clavulanic Acid.. J Apither. 2020; 7(2): 22-30. doi:10.5455/ja.20190926072142


Web Style

Khan M, Islam Z, Chowdhury AS, Yousuf SA, Amin MR, Rayhan MA. Wild Honey Facilitates Antibacterial Efficacy of Penicillin and Amoxicillin-Clavulanic Acid.. http://www.japitherapy.com/?mno=67263 [Access: April 12, 2020]. doi:10.5455/ja.20190926072142


AMA (American Medical Association) Style

Khan M, Islam Z, Chowdhury AS, Yousuf SA, Amin MR, Rayhan MA. Wild Honey Facilitates Antibacterial Efficacy of Penicillin and Amoxicillin-Clavulanic Acid.. J Apither. 2020; 7(2): 22-30. doi:10.5455/ja.20190926072142



Vancouver/ICMJE Style

Khan M, Islam Z, Chowdhury AS, Yousuf SA, Amin MR, Rayhan MA. Wild Honey Facilitates Antibacterial Efficacy of Penicillin and Amoxicillin-Clavulanic Acid.. J Apither. (2020), [cited April 12, 2020]; 7(2): 22-30. doi:10.5455/ja.20190926072142



Harvard Style

Khan, M., Islam, . Z., Chowdhury, . A. S., Yousuf, . S. A., Amin, . M. R. & Rayhan, . M. A. (2020) Wild Honey Facilitates Antibacterial Efficacy of Penicillin and Amoxicillin-Clavulanic Acid.. J Apither, 7 (2), 22-30. doi:10.5455/ja.20190926072142



Turabian Style

Khan, Mahi, Zahirul Islam, Ayreen S. Chowdhury, Syed Ali Yousuf, Md. R. Amin, and Md. Abu Rayhan. 2020. Wild Honey Facilitates Antibacterial Efficacy of Penicillin and Amoxicillin-Clavulanic Acid.. Journal of Apitherapy, 7 (2), 22-30. doi:10.5455/ja.20190926072142



Chicago Style

Khan, Mahi, Zahirul Islam, Ayreen S. Chowdhury, Syed Ali Yousuf, Md. R. Amin, and Md. Abu Rayhan. "Wild Honey Facilitates Antibacterial Efficacy of Penicillin and Amoxicillin-Clavulanic Acid.." Journal of Apitherapy 7 (2020), 22-30. doi:10.5455/ja.20190926072142



MLA (The Modern Language Association) Style

Khan, Mahi, Zahirul Islam, Ayreen S. Chowdhury, Syed Ali Yousuf, Md. R. Amin, and Md. Abu Rayhan. "Wild Honey Facilitates Antibacterial Efficacy of Penicillin and Amoxicillin-Clavulanic Acid.." Journal of Apitherapy 7.2 (2020), 22-30. Print. doi:10.5455/ja.20190926072142



APA (American Psychological Association) Style

Khan, M., Islam, . Z., Chowdhury, . A. S., Yousuf, . S. A., Amin, . M. R. & Rayhan, . M. A. (2020) Wild Honey Facilitates Antibacterial Efficacy of Penicillin and Amoxicillin-Clavulanic Acid.. Journal of Apitherapy, 7 (2), 22-30. doi:10.5455/ja.20190926072142





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