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Black Seed Honey – A Powerful Ingredient of Prophetic Medicine; Its Neuropharmacological Potential.

Abu Rayhan, Syed Ali Yousuf, Johir Rayhan, Elmabruk Khengari, Kashfia Nawrin , Mohammad Mustakim Billah.

Abstract
Introduction: Prophetic Medicine is a rich branch of natural prophylactic medicine recommended by the Prophet Muhammad (Peace Be Upon Him) and is scientifically proved to be highly effective against almost all types of ailments. Honey and Black cumin are most investigated ingredients of prophetic medicine for the scientific explanation of their benefits. The present study was designed to explore neuropharmacological potential of Honey derived from Black Seed flower.

Materials and Methods: For evaluation, novel OF-HC-EPM approach was applied on female Swiss Albino mice which was basically an integration of Open Field, Hole Cross and Elevated Plus Maze experimental cascade to trial with the rodents after single oral administration where parameters for sedative & anxiolytic behavior such as square crossing, hole crossing, grooming, rearing, entry and duration in open or close arms were observed.

Results: Dose dependent (2g/kg, 4g/kg & 6g/kg of body weight) analysis was performed against standard Diazepam (1mg/kg). At low doses (2g/kg), honey possess anxiolytic action avoiding sedation whereas at high doses (4g/kg & 6g/kg) it causes mild sedative response yet developed decision-making capability and increased confidence. On the contrary, Diazepam was associated with sedative followed by anxiolytic activity.

Conclusion: From the study, it was concluded that black seed honey exhibits non-sedative anxiolytic activity at dose dependent manner in comparison to established standard drug where sedation is often considered a limitation. Thus, as proved by black seed honey, it can be a good source for new drug development.

Key words: Black Seed Honey, Square Crossing, Rearing, Grooming, Hole Crossing, Elevated Plus Maze


 
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Pubmed Style

AR, Yousuf SA, Rayhan J, Khengari E, KN, Billah MM, . Black Seed Honey – A Powerful Ingredient of Prophetic Medicine; Its Neuropharmacological Potential.. J Apither. 2019; 5(2): 18-26. doi:10.5455/ja.20190531094932


Web Style

AR, Yousuf SA, Rayhan J, Khengari E, KN, Billah MM, . Black Seed Honey – A Powerful Ingredient of Prophetic Medicine; Its Neuropharmacological Potential.. http://www.japitherapy.com/?mno=51272 [Access: September 21, 2019]. doi:10.5455/ja.20190531094932


AMA (American Medical Association) Style

AR, Yousuf SA, Rayhan J, Khengari E, KN, Billah MM, . Black Seed Honey – A Powerful Ingredient of Prophetic Medicine; Its Neuropharmacological Potential.. J Apither. 2019; 5(2): 18-26. doi:10.5455/ja.20190531094932



Vancouver/ICMJE Style

AR, Yousuf SA, Rayhan J, Khengari E, KN, Billah MM, . Black Seed Honey – A Powerful Ingredient of Prophetic Medicine; Its Neuropharmacological Potential.. J Apither. (2019), [cited September 21, 2019]; 5(2): 18-26. doi:10.5455/ja.20190531094932



Harvard Style

, A. . R., Yousuf, S. A., Rayhan, J. ., Khengari, E., , K. N. ., Billah, M. M. & (2019) Black Seed Honey – A Powerful Ingredient of Prophetic Medicine; Its Neuropharmacological Potential.. J Apither, 5 (2), 18-26. doi:10.5455/ja.20190531094932



Turabian Style

, Abu Rayhan, Syed Ali Yousuf, Johir Rayhan, Elmabruk Khengari, Kashfia Nawrin, Mohammad Mustakim Billah, and . 2019. Black Seed Honey – A Powerful Ingredient of Prophetic Medicine; Its Neuropharmacological Potential.. Journal of Apitherapy, 5 (2), 18-26. doi:10.5455/ja.20190531094932



Chicago Style

, Abu Rayhan, Syed Ali Yousuf, Johir Rayhan, Elmabruk Khengari, Kashfia Nawrin, Mohammad Mustakim Billah, and . "Black Seed Honey – A Powerful Ingredient of Prophetic Medicine; Its Neuropharmacological Potential.." Journal of Apitherapy 5 (2019), 18-26. doi:10.5455/ja.20190531094932



MLA (The Modern Language Association) Style

, Abu Rayhan, Syed Ali Yousuf, Johir Rayhan, Elmabruk Khengari, Kashfia Nawrin, Mohammad Mustakim Billah, and . "Black Seed Honey – A Powerful Ingredient of Prophetic Medicine; Its Neuropharmacological Potential.." Journal of Apitherapy 5.2 (2019), 18-26. Print. doi:10.5455/ja.20190531094932



APA (American Psychological Association) Style

, A. . R., Yousuf, S. A., Rayhan, J. ., Khengari, E., , K. N. ., Billah, M. M. & (2019) Black Seed Honey – A Powerful Ingredient of Prophetic Medicine; Its Neuropharmacological Potential.. Journal of Apitherapy, 5 (2), 18-26. doi:10.5455/ja.20190531094932





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