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Original Research (Original Article) 


Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model

İhsan Karaboğa.

Abstract
Aim: This study was conducted to explain the anti-inflammatory activity of caffeic acid phenethyl ester (CAPE) in an experimental rat thoracic trauma model. Materials and Methods: Forty adult (200 - 250 g) male Wistar albino rats were used. Rats were randomly divided into 4 groups; Control (n=10), Trauma model (n=10), Trauma model + CAPE (n=10) and CAPE (n=10) groups, respectively. CAPE treatment was administered intraperitoneally at a dose of 10 µmol/kg for seven days. At the end of the seventh day, the rats were sacrificed under anesthesia. Serum interleukin 1-beta (IL-1β), interleukin-6 (IL-6) and interleukin-10 cytokine levels were determined as pg/ml using the sandwich ELISA method. Results: In the trauma model, there was increased IL-1β and IL-6 and decreased pro-inflammatory IL-10 serum levels compared to the control group (p<0.05). CAPE treatment resulted in a decrease in IL-1β and IL-6 levels and an increase in IL-10 levels (p<0.05). Conclusion: CAPE administration suppresses systemic inflammation in the thoracic trauma model by reducing the expression of pro-inflammatory cytokines IL-1β and IL-6 and increasing the expression of anti-inflammatory IL-10.

Key words: Cytokines, Tumor necrosis factor alpha, Interleukine-6, Interleukine-10


 
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Pubmed Style

Ihsan Karaboga. Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model. J Apither. 2018; 3(2): 31-35. doi:10.5455/ja.20180702102008


Web Style

Ihsan Karaboga. Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model. http://www.japitherapy.com/?mno=301363 [Access: November 15, 2018]. doi:10.5455/ja.20180702102008


AMA (American Medical Association) Style

Ihsan Karaboga. Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model. J Apither. 2018; 3(2): 31-35. doi:10.5455/ja.20180702102008



Vancouver/ICMJE Style

Ihsan Karaboga. Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model. J Apither. (2018), [cited November 15, 2018]; 3(2): 31-35. doi:10.5455/ja.20180702102008



Harvard Style

Ihsan Karaboga (2018) Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model. J Apither, 3 (2), 31-35. doi:10.5455/ja.20180702102008



Turabian Style

Ihsan Karaboga. 2018. Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model. Journal of Apitherapy, 3 (2), 31-35. doi:10.5455/ja.20180702102008



Chicago Style

Ihsan Karaboga. "Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model." Journal of Apitherapy 3 (2018), 31-35. doi:10.5455/ja.20180702102008



MLA (The Modern Language Association) Style

Ihsan Karaboga. "Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model." Journal of Apitherapy 3.2 (2018), 31-35. Print. doi:10.5455/ja.20180702102008



APA (American Psychological Association) Style

Ihsan Karaboga (2018) Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model. Journal of Apitherapy, 3 (2), 31-35. doi:10.5455/ja.20180702102008





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