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Original Research (Original Article) 


Chemical and biological diversity of propolis samples from Bulgaria, Libya and Egypt

Farid A. Badria, Hassan M. Fathy, Ashraf S. Fatehe, Mohamed H. Ahmed, Mohamed G. Ghazy.

Abstract
Introduction: Propolis is an important characteristic because it contains bioactive substances such as total phenolics, total flavones, flavonols, total flavanones and dihydroflavonols. Cancer is a large group of disorders characterized by uncontrolled cellular proliferation. It is one of the most devastating diseases all over the world. Recently, there is an increased interest in the clinical use of natural products as a safe, efficient, and economic therapeutic alternative. Honey bee products therapy, apitherapy, was used to control various diseases including cancer. Objectives: The primary objective of this study was to screen potential cytotoxic effects of propolis sample against different cancer types. Materials and Methods: Samples of propolis were collected from Bulgaria, Libya and Egypt and tested by MTT cell-based assay against liver (HEP-G2), breast (MCF-7) and colorectal (Caco-2) cancer cell lines. Results: The results showed that Libyan propolis proved to be most active among all tested propolis samples HEP-G2 (84.99%), MCF-7 (83.57%) and Caco-2 (79.63%). Conclusion: The results showed that propolis it is interesting agents that have valuable activities against HEP-G2, Caco-2 and MCF-7 with propolis being an effective agent that might be incorporated in cancer remedy regimens after further studies.

Key words: Apitherapy, HEP-G2, Caco-2, MCF-7, Propolis


 
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How to Cite this Article
Pubmed Style

Badria FA, Fathy HM, Fatehe AS, Ahmed MH, Ghazy MG. Chemical and biological diversity of propolis samples from Bulgaria, Libya and Egypt. J Apither. 2018; 3(2): 17-23. doi:10.5455/ja.20180428014109


Web Style

Badria FA, Fathy HM, Fatehe AS, Ahmed MH, Ghazy MG. Chemical and biological diversity of propolis samples from Bulgaria, Libya and Egypt. http://www.japitherapy.com/?mno=297874 [Access: November 17, 2019]. doi:10.5455/ja.20180428014109


AMA (American Medical Association) Style

Badria FA, Fathy HM, Fatehe AS, Ahmed MH, Ghazy MG. Chemical and biological diversity of propolis samples from Bulgaria, Libya and Egypt. J Apither. 2018; 3(2): 17-23. doi:10.5455/ja.20180428014109



Vancouver/ICMJE Style

Badria FA, Fathy HM, Fatehe AS, Ahmed MH, Ghazy MG. Chemical and biological diversity of propolis samples from Bulgaria, Libya and Egypt. J Apither. (2018), [cited November 17, 2019]; 3(2): 17-23. doi:10.5455/ja.20180428014109



Harvard Style

Badria, F. A., Fathy, . H. M., Fatehe, . A. S., Ahmed, . M. H. & Ghazy, . M. G. (2018) Chemical and biological diversity of propolis samples from Bulgaria, Libya and Egypt. J Apither, 3 (2), 17-23. doi:10.5455/ja.20180428014109



Turabian Style

Badria, Farid A., Hassan M. Fathy, Ashraf S. Fatehe, Mohamed H. Ahmed, and Mohamed G. Ghazy. 2018. Chemical and biological diversity of propolis samples from Bulgaria, Libya and Egypt. Journal of Apitherapy, 3 (2), 17-23. doi:10.5455/ja.20180428014109



Chicago Style

Badria, Farid A., Hassan M. Fathy, Ashraf S. Fatehe, Mohamed H. Ahmed, and Mohamed G. Ghazy. "Chemical and biological diversity of propolis samples from Bulgaria, Libya and Egypt." Journal of Apitherapy 3 (2018), 17-23. doi:10.5455/ja.20180428014109



MLA (The Modern Language Association) Style

Badria, Farid A., Hassan M. Fathy, Ashraf S. Fatehe, Mohamed H. Ahmed, and Mohamed G. Ghazy. "Chemical and biological diversity of propolis samples from Bulgaria, Libya and Egypt." Journal of Apitherapy 3.2 (2018), 17-23. Print. doi:10.5455/ja.20180428014109



APA (American Psychological Association) Style

Badria, F. A., Fathy, . H. M., Fatehe, . A. S., Ahmed, . M. H. & Ghazy, . M. G. (2018) Chemical and biological diversity of propolis samples from Bulgaria, Libya and Egypt. Journal of Apitherapy, 3 (2), 17-23. doi:10.5455/ja.20180428014109





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