E-ISSN 2474-137X
 

Original Research (Original Article) 


Evaluate the cytotoxic activity of honey, propolis, and bee venom from different localities in Egypt against liver, breast, and colorectal cancer

Farid Abd-Elrehim Abd-elaziz Badria, Hassan Mohamed Fathy, Ashraf Sherif Fatehe, Diaaeldin Mohamed Abdelkawi Elimam, Mohamed Ghazy Mohamed Ghazy.

Cited by (2)

Abstract
Cancer is a large group of disorders characterized by uncontrolled cellular proliferation. It is one of the most devastating diseases all over the world. Recently, there is an increased interest in the clinical use of natural products as a safe, efficient, and economic therapeutic alternative. Honey bee products therapy, apitherapy, was used to control various diseases including cancer. In this study, samples of honey, venom and propolis were collected from different Egyptian localities with different techniques and tested by MTT cell-based assay against liver (HePG2), breast (MCF-7), and colorectal (Caco-2) cancer cell lines. The results showed that, Italian dissected method-bee venom was the most active among all the tested samples against Hep-G2 (93.92%), Caco-2 (93.92%) and MCF-7 (90.17%). However, Libyan propolis proved to be most active among all tested propolis samples. On the other hand, all tested honey samples showed non-remarkable activities except Asyut-clover honey (49.84% against Caco-2 cell line).

Key words: Apitherapy, HepG2, Caco-2, MCF-7, Honey, Propolis, Bee venom


 


Most Viewed Articles
  • Welcome to Journal of Apitherapy
    Editor
    J Apither. 2016; 1(1): 1-1
    » Abstract & References » doi: 10.5455/ja.20160509012435

  • Honey and its uses in oral diseases- An overview
    Santosh R Patil, Ravi Kumar Gudipaneni
    J Apither. 2016; 1(1): 17-19
    » Abstract & References » doi: 10.5455/ja.20160428110757

  • The value of Mountain Sidr Honey in treating and controlling chronic constipation: A Prospective comparative study between Ziziphus honey and Lactulose in 1000 Saudi Arabian patients
    Bader Hamza Shirah, Hamza Asaad Shirah
    J Apither. 2016; 1(1): 2-6
    » Abstract & References » doi: 10.5455/ja.20160507094522

  • Wound healing with Apitherapy: A Review of the Effects of Honey
    Michael Malone, Gary Tsai
    J Apither. 2016; 1(1): 29-32
    » Abstract & References » doi: 10.5455/ja.20160620031837

  • Study on antibacterial efficacy of different honey types in South Western Nigeria against wound associated bacteria
    Rasheed Omotayo Adeyemo, Nkem Torimiro, Saheed Adekunle Akinola, Sodiq Kolawole Lawal, Tesleem Olatunde Abolarinwa, Wasiu Olalekan Adewoye
    J Apither. 2017; 2(1): 15-19
    » Abstract » doi: 10.5455/ja.20170309062135

  • Most Downloaded
  • Health Benefits and Traditional Uses of Honey: A Review
    Menuka - Arawwawala, sujatha - Hewageegana
    J Apither. 2017; 2(1): 9-14
    » Abstract » doi: 10.5455/ja.20170208043727

  • The effects of honey supplementation on Egyptian children with hepatitis A: A randomized double blinded placebo controlled pilot study
    Mamdouh Abdulmaksoud Abdulrhman, Rania Shatla, Sahar Mohamed
    J Apither. 2016; 1(1): 23-28
    » Abstract & References » doi: 10.5455/ja.20160702011113

  • Wound healing with Apitherapy: A Review of the Effects of Honey
    Michael Malone, Gary Tsai
    J Apither. 2016; 1(1): 29-32
    » Abstract & References » doi: 10.5455/ja.20160620031837

  • The value of Mountain Sidr Honey in treating and controlling chronic constipation: A Prospective comparative study between Ziziphus honey and Lactulose in 1000 Saudi Arabian patients
    Bader Hamza Shirah, Hamza Asaad Shirah
    J Apither. 2016; 1(1): 2-6
    » Abstract & References » doi: 10.5455/ja.20160507094522

  • Evaluate the cytotoxic activity of honey, propolis, and bee venom from different localities in Egypt against liver, breast, and colorectal cancer
    Farid Abd-Elrehim Abd-elaziz Badria, Hassan Mohamed Fathy, Ashraf Sherif Fatehe, Diaaeldin Mohamed Abdelkawi Elimam, Mohamed Ghazy Mohamed Ghazy
    J Apither. 2017; 2(1): 1-8
    » Abstract » doi: 10.5455/ja.20170203075953

  • Most Cited Articles
  • Wound healing with Apitherapy: A Review of the Effects of Honey
    Michael Malone, Gary Tsai
    J Apither. 2016; 1(1): 29-32
    » Abstract & References » doi: 10.5455/ja.20160620031837
    Cited : 4 times [Click to see citing articles]

  • Propolis as an alternative in prevention and control of dental cavity
    Bárbara Soares Machado, Tarcyane Neves Pulcino, Ayalla Lima Silva, Diego Tadeu Melo, Renata Gomes Silva, Izabel Gomes Mendonça
    J Apither. 2016; 1(2): 47-50
    » Abstract » doi: 10.5455/ja.20160726115117
    Cited : 3 times [Click to see citing articles]

  • Melittin and Cancer
    Anna Tacón, Ph.D.
    J Apither. 2016; 1(2): 51-54
    » Abstract » doi: 10.5455/ja.20161027091813
    Cited : 2 times [Click to see citing articles]

  • Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model
    İhsan Karaboğa
    J Apither. 2018; 3(2): 31-35
    » Abstract » doi: 10.5455/ja.20180702102008
    Cited : 2 times [Click to see citing articles]

  • Meaningfulness of Apitherapeutic Approaches Using the Example of Primary Dysmenorrhoea
    Karsten Münstedt
    J Apither. 2018; 3(1): 9-16
    » Abstract » doi: 10.5455/ja.20170917090943
    Cited : 2 times [Click to see citing articles]

  • ARTICLE TOOLS
    Abstract
    PDF Fulltext
    This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.

    The articles in Journal of Apitherapy are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
    Copyright © 2020 Journal of Apitherapy All Rights Reserved. Subject to change without notice from or liability to Journal of Apitherapy.
    For best results, please use Internet Explorer or Google Chrome


    Contact Information



    Your comments are very important to us

    We welcome your ideas, suggestions, comments, or questions. To reach Editorial Board please use one of the methods provided below.
     
    Email us at info[at]scopemed.com
     
    We will respond within 48 to 72 hours.
     
    Change of address or personal information? Please visit your account at www.ejmanager.com to update your information.